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Scientists accidentally turn gene-edited hamsters into hyper aggressive demons in experiment

A team of scientists at the Georgia State University (GSU) were left speechless after an experiment involving gene-editing on hamsters turned them into hyper aggressive little demons.

To conduct research into the biology behind the social behaviour of mammals, the GSU team used CRISPR-Cas9—an incredible type of gene therapy technology that can turn genes on and off in cells—on Syrian hamsters. They used such technology to ‘turn off’ a vasopressin receptor in the little creatures, which is the hormone responsible for aggression. 

In theory, the scientists believed this would alter the social behaviour of the hamsters drastically and result in them becoming more peaceful. While their behaviour did change, it wasn’t in the direction expected.

Professor H. Elliot Albers and Professor Kim Huhman were both very surprised by the outcome, “We anticipated that if we eliminated vasopressin activity, we would reduce both aggression and social communication. But the opposite happened.”

Instead, the hamsters became even more social than ever before, with their aggression towards members of the same sex greatly escalating and resulting in them chasing, biting and pinning each other down.

Albers believes this startling conclusion shows how much there is yet to learn about the biological system involved. “We don’t understand this system as well as we thought we did. The counterintuitive findings tell us we need to start thinking about the actions of these receptors across entire circuits of the brain and not just in specific brain regions.”

The use of Syrian hamsters specifically has been extremely important in understanding social behaviours, aggression and communication. They were the first animal in which the vasopressin hormone was shown to influence social behaviour. Their social organisation is much more similar to humans, which makes them the perfect research subjects, explained Huhman.

“Their stress response is more like that of humans than it is other rodents. They release the stress hormone cortisol, just as humans do. They also get many of the cancers that humans get,” she continued.

While this is a big step forward in gene editing technology, there is still a long way to go before this type of research can be undertaken on human subjects.

Guess what? One of the world’s largest animals can glow in the dark

According to a study conducted by marine biologist Jérôme Mallefet, three specific species of sharks can glow in the dark. I know what you’re thinking, ‘sharks that glow in the dark?’, get outta here. But no, it is true my friends. And yes, they are just as beautiful as you can imagine. What are these magical creatures, why have they only been discovered now, and how exactly do they glow?

The kitefin shark (Dalatias licha) is approximately the size of your average guitar. In normal light it has a brownish-black skin, with large and slightly googly eyes. But turn the lights off, and it emits an almost translucent and ghostly blue glow. On a 2020 voyage near Chatham Rise, which is just off the coast of New Zealand, a team of international scientists discovered that not only the kitefin shark, but two other species of deep sea sharks have the same gloriously bioluminescent traits. The blackbelly lanternshark (Etmopterus lucifer) and the southern lanternshark (Etmopterus granulosus) have been added to the list, although the kitefin shark takes first place for being the largest known vertebrate to produce such a glow.

The three sharks inhabit the mesopelagic zone of the ocean, which is also known as the twilight zone, and ranges from 200 to 1000 meters in depth—so obviously not a whole lot of sunlight can flood that range, providing an illuminated glow instead. According to Mallefet, most marine organisms that produce bioluminescence contain special chemicals, including a compound called luciferin that interacts with oxygen to produce light. Jellyfish, squid and algae (which are not vertebrates) for example, also enjoy luciferin. But these three shark species do not appear to contain the same chemical properties, so their ability to emit light “remains enigmatic.”

In an interview with Mongabay, Mallefet said that “For the moment our conclusion is that, maybe sharks have a new component that is unknown, But we don’t know.” As anything in nature, everything has a purpose, which is not only beautiful but inspiring when compared to how humans have evolved enough to take advantage of their surroundings.

With humanity set on living in the stars, we have neglected much of the vastness that Earth has to offer. Mallefet continues by explaining that “Many people say the deep sea is less known than the surface of the moon. We hope by highlighting something new in the deep sea of New Zealand—glowing sharks—that maybe people will start thinking we should protect this environment before destroying it. I hope the new generation will carry that message.”

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Bioluminescent sharks emit light from specialised cells on the surface of their skin known as photocytes, but exactly how they do this has long been a mystery, however, the study that Mallefet and his colleagues conducted shows some interesting data: the species control their light emissions using hormones. The luminescence is turned on by melatonin, which in humans, is there to help us effectively mediate dark signals and provide night information. Melatonin has been described by the Psychiatric Times as a “hormone of darkness” rather than the ‘hormone of sleep’ we all hear about. It has also been thought to be an endogenous synchroniser that stabilises as well as reinforces various circadian rhythms in the body—the same goes for all mammals, but sharks however are of the Chondrichthyes class.

So why do sharks, among other creatures, have the ability to light up in the first place? Well, in the deep sea, scientists estimate that around three quarters of all creatures living there are bioluminescent, which in the context of darkness, can be extremely advantageous. Need I say more? I will anyway, because it’s fascinating.

Deep sea animals use this special power to do everything from attracting prey and deterring predators to using it as a means to camouflage by hiding their silhouettes to match the light around them, in turn becoming practically invisible to those big bad scaries lurking below. This trick is called counter illumination.

In the case of sharks, known as the biggest and baddest of many, the fact that there might be something after them too for supper remains a possibility. However, because of the dense concentration of photocytes that were found on the dorsal fins of the kitefin sharks, there is speculation that it might simply happen as a way to help sharks communicate with each other.

For now, it’s important to know that these creatures and their habitats are understudied, and under threat. “A lot of people know that sharks can bite, thanks to Jaws,” says Mallefet, “but few people know that they can glow in the dark.” Now for a second, look down at your hands and skin, and imagine how truly remarkable this really is.